Safe and Natural Protection Against Adhesions
Anika’s all-natural hyaluronic acid (HA)-based anti-adhesion products work to prevent or reduce post-surgical adhesions, a common complication after a variety of surgical procedures.
Hyalobarrier Gel /Hyalobarrier Gel Endo
Hyalobarrier® Gel and Hyalobarrier Gel Endo are sterile, transparent and highly viscous gels that form a barrier to prevent or reduce post-surgical adhesions in the abdomino-pelvic area. They are composed of highly purified, auto cross-linked polysaccharide (ACP®) of hyaluronic acid, one of the main components of human connective tissue and of epithelial and mesothelial tissues.
Hyalobarrier adheres to the tissue surface and to the abdominal wall, creating a physical antiadhesion barrier after surgery, which keeps the adjacent tissues separated during the healing process, protecting against adhesions. The anti-adhesion gel is then completely resorbed into the body over time. The devices have proven clinical safety and efficacy results in different clinical settings.1-14
Key Features & Benefits
- Safe and effective against adhesion formation
- Quick and easy application
Hyalobarrier is not approved for use in the United States.
Hyaloglide /Hyaloglide mini
Hyaloglide® and Hyaloglide mini are transparent, highly viscous gels used to prevent or reduce adhesions following tendon and/or peripheral nerve and/or articular surgery. Hyaloglide is composed of a highly purified, auto cross-linked polysaccharide (ACP) of hyaluronic acid, one of the main components of human connective tissue and of epithelial and mesothelial tissues. As a result of its viscosity, Hyaloglide perfectly adheres to the surface of the tissue, creating an anti-adhesion barrier which keeps the adjacent tissues separated during the healing process. The anti-adhesion gel is completely resorbed over time. The devices have proven clinical safety and efficacy results in different clinical settings.15-21
Key Features & Benefits
- Safe and effective against adhesion formation
- Quick and easy application
Hyaloglide is not approved for use in the United States.
Anika’s hyaluronic acid (HA)-based ENT products are composed of HYAFF®, an ester of hyaluronic acid, a naturally occurring constituent of the extracellular matrix. They act in the nasal/sinus and the middle ear/ external ear canal as space occupying dressing and/or stent, to separate mucosal surfaces and to help control minimal bleeding following surgery, and in otologic packing, as an adjunct to aid in the natural healing process. In contact with body fluids, they change into a viscous and transparent gel conforming to mucosal surfaces, and eventually dissolve or may be irrigated from the cavity. They have proven clinical safety and efficacy results in different clinical settings.22-40
Key Features & Benefits
- Safe and effective
Anika products may not be available in all geographies. Product availability is subject to the regulatory clearances in individual markets. Please reach out to your local representative or Contact Us if you have questions about specific market approvals.
For complete product information, including indications, contraindications, warnings, and precautions, please refer to the Instructions for Use provided with the product or Contact Us for a copy.
Hyalobarrier gel/ Hyalobarrier gel endo
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- Hooker AB, de Leeuw RA, Twisk JWR, Brölmann HAM, Huirne JAF. Pregnancy and neonatal outcomes 42 months after application of hyaluronic acid gel following dilation and curettage for miscarriage in women who have experienced at least one previous curettage: follow-up of a randomized controlled trial. Fertil Steril. 2020 Sep;114(3):601-609
- Cheng M, Chang WH, Yang ST, Huang HY, Tsui KH, Chang CP, Lee WL, Wang PH. Efficacy of Applying Hyaluronic Acid Gels in the Primary Prevention of Intrauterine Adhesion after Hysteroscopic Myomectomy: A Meta-Analysis of Randomized Controlled Trials. Life (Basel). 2020 Nov 15;10(11):285
- Barra V, Chiacchio A., Di Rienzo G., Gison M., De Roberto C. Clinical outcome of flexor tendon repair in zone 2 with Hyaloglide. Riv Chir Mano 2006; 43 (1):54-60
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- Atzei A, Calcagni M, Breda B, Fasolo G, Pajardi G, Cugola L. Clinical evaluation of a hyaluronan-based gel following microsurgical reconstruction of peripheral nerves of the hand. Microsurgery. 2007; 27(1):2-7.
- Riccio M, Battiston B, Pajardi G, Corradi M, Passaretti U, Atzei A, Altissimi M, Vaienti L, Catalano F, Del Bene M, Fasolo P, Ceruso M, Luchetti R, Landi A; Study Group on Tendon Adhesion of Italian Society of Hand Surgery. Efficiency of Hyaloglide in the prevention of the recurrence of adhesions after tenolysis of flexor tendons in zone II: a randomized, controlled, multicenter clinical trial. J Hand Surg Eur Vol. 2010 Feb; 35(2):130-8. Epub 2009 Aug 26.
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- Saliba I, Knapik M, Froehlich P, Abela A Advantages of hyaluronic Acid fat graft myringoplasty over fat graft myringoplasty. Arch Otolaryngol Head Neck Surg. 2012 Oct 1; 138(10):950-5.
- Alzahrani M, Saliba I.Hyaluronic acid fat graft myringoplasty vs fat patch fat graft myringoplasty. Eur Arch Otorhinolaryngol. 2014 Mar 15. [Epub ahead of print]
- Gün T, Boztepe OF, Atan D., İkincioğulları A, Dere H. Comparison of Hyaluronic Acid Fat Graft Myringoplasty, Fat Graft Myringoplasty and Temporal Fascia Techniques for the Closure of Different Sizes and Sites of Tympanic Membrane Perforations. Int Adv Otol 2016; 12: 137-141
- Ballivet de Régloix S, Crambert A, Salf E, Maurin O, Pons Y, Clément P. Early Tympanoplasty Using a Synthetic Biomembrane for Military-Related Blast Induced Large Tympanic Membrane Perforation. Mil Med. 2018 Nov 1;183(11-12): e624-e627.
- Wong WK, Luu EH. What is the Role of Hyaluronic Acid Ester in Myringoplasty? Systematic Review and Meta-Analysis. Otol Neurotol. 2019 Aug;40(7):851-857.
- Tashjian M, Ruiz A, Dinwiddie J, Greenlee C, Wine T. Cost of closure: Comparing success and spending of fat graft myringoplasties with and without hyaluronic acid. Int J Pediatr Otorhinolaryngol . 2020 Aug;135: 110104. Epub 2020 May 24.
- Miller RS, Steward DL, Tami TA, Sillars MJ, Seiden AM, Shete M, Paskowski C, Welge J..The clinical effects of hyaluronic acid ester nasal dressing (Merogel) on intranasal wound healing after functional endoscopic sinus surgery. Otolaryngol Head Neck Surg, 2003. 128(6): p. 862-9
- Catalano PJ, Roffman EJ. Evaluation of middle meatal stenting after minimally invasive sinus techniques (MIST). Otolaryngol Head Neck Surg, 2003. 128 (6): p. 875
- Xu G, Chen HX, Wen WP, Shi JB, Li Y. Clinical evaluation of local application of Merogel after endoscopic sinus surgery. Zhonghua Er Bi Yan Hou Ke Za Zhi, 2003. 38(2): p. 95-7
- Franklin, J.H. and E.D. Wright, Randomized, controlled, study of absorbable nasal packing on outcomes of surgical treatment of rhinosinusitis with polyposis. Am J Rhinol, 2007. 21(2): p. 214-7
- Berlucchi M, Castelnuovo P, Vincenzi A, Morra B, Pasquini E. Endoscopic outcomes of resorbable nasal packing after functional endoscopic sinus surgery: a multicenter prospective randomized controlled study. Eur Arch Otorhinolaryngol. 2009 Jun; 266(6):839-45. Epub 2008 Oct 23
- Wu W, Cannon PS, Yan W, Tu Y, Selva D, Qu J. Effects of Merogel coverage on wound healing and ostial patency in endonasal endoscopic dacryocystorhinostomy for primary chronic dacryocystitis. Eye (Lond). 2011 Jun; 25(6):746-53
- Song KJ, Lee HM, Lee EJ, Kwon JH, Jo KH, Kim KS. Anti-adhesive effect of a thermosensitive poloxamer applied after the removal of nasal packing in endoscopic sinus surgery: a randomised multicentre clinical trial. Clin Otolaryngol. 2013 Jun;38(3):225-30
- Qian Z, Tu Y, Xiao T, Wu W. A Lacrimal Sump Syndrome. With a Large Intranasal Ostium. J Craniofac Surg. 2015 Jul; 26 (5): e386-8
- Deng R, Fang Y, Shen J, Ou X, Liuyan W, Wan B, Yuan Y, Cheng X, Shu Y, Chen B. Effect of esterified hyaluronic acid as middle ear packing in tympanoplasty for adhesive otitis media. Acta Otolaryngol. 2018 Feb; 138 (2): 105-109. Epub 2017 Oct 26